That's exactly what lead nurture emails are designed for and how I use them to accomplish what you're trying to do. Since it's a campaign email, opens are automatically tracked.
We send emails based on certain criteria such as their purchase date. 11 months after their purchase date a workflow fires off an email asking the customer to schedule their Annual System Review with their Account Manager. Then they get re-enrolled in the workflow 1-year later. Then we have a special email report the runs monthly specifically tracking the metrics for this campaign.