Anyone else seeing caching issues with script file updates on sandboxes? One of ours isn't picking up any changes at all

including changes from the user interface?

yes

what is it with me in that although I work with many different NS accounts, I am not seeing this behavior? Just lucky?

A colleague ended up doing a re-save on the file & it picked it up

I experienced this as well in an account. In addition to the general script caching issue that has been referenced overall, it seemed the actual Owner of the script additionally had to be the one to manually update the contents in the UI 🤦‍♂️

Yes!