My company has entities that we buy from and sell to (ie: both customer and vendor). I am looking at using the "Other Relationship" feature as they are one record, but treated separated (ie: different debtors and creditors balances). Any best practice or potential pitfalls I should be aware of? TIA !

I think some people advise not to, you can have a customer/vendor on the same record but it gets very tricky to undo it once the join has been made.