Is there a way to set a minimum cost for an item (say $350) and then have each unit thereafter be $ 1.55?

I guess you will need to be more specific? Are talking about quantity pricing?

Yes. But since I can only used whole numbers for the quantity the minimum is either a bit over or under the actual. So in my example - anything under 225.8 should show a cost of $ 350.00 but since I cannot use that number if I show 225 as the minimum qty the minimum cost comes out to $ 348.75.

Is it because you are using custom units?

correct. in my case the charge is per lb.

Try to use your pricing in kg, netsuite should convert itself.

I tried thast but still am coming a few cents off the real minimum. I thought there would be a way to just show a Minimum amount and then a per lb (or kg) rate.

I'm sorry, I won't be able to help here 😞