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For Celigo purposes, Is its possible to cancel and resubmit new fulfillment data via REST or GraphQL?

If the api has PUT options then typically or maybe you delete what you made and then post again

Yes, after you've already submitted once.

Without looking at any api docs, I can't really say. As long as their api supports doing PUTs or DELETES then I don't see why you couldn't do what you need