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I have a suitelet with a sublist and many entries. In the suitelet I have a button "Hide". When click on it, I would like to hide few entries in the Sublist. Is it possible ?

Yes, you need to attach a client script to your suitelet and implement the logic there as usual

Am I right to believe that I have to define the sublist in the suitelet, then in client getting the sublist (one way or another)

Shout, still not working,  it doesn't show errors but the sublist does not get refresh
I know I'm asking a lot, but do you see an error in the code below ? alert _aa is workingi fine

        var record = context.currentRecord;
        var _aa = record.getSublistValue({sublistId: 'custpage_sublist',fieldId: 'custpage_customer',line: 1}) ;
alert (_aa );
        record.selectLine({sublistId: 'custpage_sublist',line: 1});
        record.setCurrentSublistValue({sublistId: 'custpage_sublist',fieldId: 'custpage_city',value: 'Good afternoon',ignoreFieldChange: false});
        record.commitLine({sublistId: 'custpage_sublist'});