Bug with summary level search plus available filter (or even criteria) that produces incorrect values.
I know of one configuration of search and available filter/criteria that causes this issue (item search and 'Name' filter/criteria), but there could be others.
The issue is caused by the 'Name' available filter/criteria searching multiple fields (item id, vendor code, and I believe the vendor codes under Purchasing/Inventory > Vendors).
This produces duplicate matches for the summary search, and when you're using the SUM summary type (maybe also affects Average?) the search shows some multiple of the actual value (depends on the number of matches, I've seen 2x and 3x)
In my example screenshots below I'm using available filter instead of criteria so you can see the effect better.
The item only has one on hand, as seen in the first screenshot (no filter applied), and in the last screenshot (non-summary/drill down search).
Searching for the item name in the available filter incorrectly changes the value of the SUM On Hand field.