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anyone know the setting where an invoice can deduct inventory?

Invoice only reduce inventory if it is not created from sales order. There is no setting it's standard behaviour.

Are your using inventory item and does that item have inventory on hand if not then no cogs will be posted if this is 1st time you using this item and there is no last purchase price or average cost.

Sales order are non posting and item fulfillment is posting.

Have you selected right location on the line or header on the invoice.

If you create an invoice from a sales order- you must use an item fulfillment to decrement inventory and hit cogs

if you create an invoice as standalone - then it will remove inventory from hand and hit cogs automatically. There is no setting for controlling that.

If you are seeing no inventory impact - then I'd probably make sure the item has all the appropriate accounts setup and that it's inventory on hand has dollar values associated with it.